Interactions of CBD Oil and Drugs

cannabidiol drug interactions

CBD oil has a plethora of health benefits with very few adverse effects. There is sufficient research available now to infer that CBD oil does not have many unintended effects, especially serious impacts on health or various vital functions. It is not premature to conclude that CBD oil is safe and can be used or consumed with no major complications. However, there are some potential interactions of CBD oil and drugs. One must understand the forms of interactions and the possible risks.

CBD Oil and the CYP450 Pathway

CBD oil can inhibit the CYP450 or cytochrome P450 enzyme system while interacting within the endocannabinoid system. The CYP450 or cytochrome P-450 enzyme system is in the liver and metabolizes toxic substances. It also works on compounds that are potentially toxic. As a result, more than sixty percent of all drugs consumed are metabolized by the cytochrome P-450 enzyme system in the liver. There are over fifty enzymes in this system, which are responsible for processing and subsequent elimination of the toxins. If the CYP450 pathway does not function normally, there can be serious consequences or health complications.

Dosage of different drugs is determined by doctors after calculating the time needed for the CYP450 pathway to process and eliminate the toxins. Medicines, whether over the counter or prescription drugs, take varying times to pass through the pathway. For the system to be healthy, one must not be exposed to more drugs and hence toxins than what the pathway can manage at any given time. Other substances can influence the processing time of different drugs in the pathway. Thus, regulating exposure to such substances is necessary. Unpleasant exposure can slow down the metabolizing of potent drugs.

Interaction of Cannabidiol and Cytochrome P-450 System

Cannabidiol or CBD oil can reduce the ability of the cytochrome P450 system to metabolize some drugs. This will lead to an immediate increase in time required to process an ingested drug. As a result, there can be increased toxicity. CBD oil is just one of the many substances that can affect drug metabolism. Watercress, goldenseal, watercress and St. John’s Wort can also impair the efficacy of the CYP450 pathway.

Since CBD oil can inhibit the functioning of the CYP450 pathway or enzyme system, cannabidiol can interact with drugs that are not properly metabolized in the liver. The efficacy of the drugs may suffer. Some drugs may become more potent. The risks associated with strong drugs may become graver. Some drugs may not be metabolized substantially to have any desired effect. There can also be overdosing if the pathway is unable to get rid of the toxins from certain drugs.

These possibilities make it imperative for those taking CBD oil to consult a doctor if they are already taking some other medicines, especially those that can be toxic. It is not necessary to avoid CBD oil usage completely. The dosage of a prescribed medicine and the manner in which you may use cannabidiol can be altered to ensure the CYP450 pathway is not affected or inhibited in any way.

Interaction of Cannabidiol with Drugs

All drugs that are metabolized in the CYP450 pathway by the fifty odd enzymes can interact with CBD oil or cannabidiol. The drugs that definitely interact with cannabidiol are steroids, calcium channel blockers, HMG CoA reductase inhibitors, antihistamines, HIV antivirals, prokinetics, immune modulators, antibiotics, benzodiazepines, anesthetics, antiarrythmics, antipsychotics, anti-epileptics, antidepressants, beta blockers, NSAIDs, PPIs, angiotension II blockers, sulfonylureas and oral hypoglycemic agents.

There are many other drugs that can interact with cannabidiol, which is why consulting a doctor about specific medicines is the best option. Some medications that do not necessarily required the CYP450 enzymes but the CYP3A4 system to work can interact with cannabidiol. These are prodrugs that should be metabolized so their therapeutic compound is made available inside the body. A common example is Codeine. It is one of the few prodrugs that undergoes metabolism to produce the intended effects, in this case morphine. Concerta and Vyvanse are ADHD drugs that are classified as prodrugs.

Interactions of Coffee and Alcohol with CBD Oil

CBD oil has no severe or even mildly discomforting interaction with coffee. Cannabidiol and caffeine can be consumed simultaneously. However, excessive consumption should be avoided. Many people are gradually moving away from caffeine to cannabidiol. Excessive caffeine consumption is not completely safe or good for health.

Alcohol consumption and cannabidiol do not necessarily pose any threat. However, binge drinking or chronic consumption of alcohol do pose long term risks. Those who drink occasionally or socially will have no problems with cannabidiol. Even those who drink regularly may benefit from using cannabidiol. The alcohol content in blood is better regulated by CBD oil. However, substance abuse of any kind has adverse effects.

CBD oil is not as addictive as coffee or alcohol. It is hence a much better alternative, whether for therapeutic purposes or recreation.

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